ea0063p1018 | Interdisciplinary Endocrinology 2 | ECE2019
Vu Thi-An
, Lema Ingrid
, Bouligand Jerome
, Martinerie Laetitia
, Lombes Marc
, Viengchareun Say
The Mineralocorticoid Receptor (MR), a hormone-activated transcription factor that mediates sodium-retaining action of aldosterone, is highly expressed in the distal nephron in which large variations in extracellular fluid tonicity are generated by the cortico-papillary gradient. However, mechanisms regulating MR expression remain sparse. We recently showed that extracellular tonicity modulates renal MR expression through posttranscriptional mechanisms (Viengchareun, Mol Endoc...